METAL-ION REGULATION OF GENE-EXPRESSION IN YEAST

Citation
Dr. Winge et al., METAL-ION REGULATION OF GENE-EXPRESSION IN YEAST, CURRENT OPINION IN CHEMICAL BIOLOGY, 2(2), 1998, pp. 216-221
Citations number
43
Categorie Soggetti
Biology,Biophysics
ISSN journal
13675931
Volume
2
Issue
2
Year of publication
1998
Pages
216 - 221
Database
ISI
SICI code
1367-5931(1998)2:2<216:MROGIY>2.0.ZU;2-B
Abstract
Metal-responsive transcription factors exist in yeast to modulate expr ession of genes that encode proteins involved in cellular uptake of co pper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-spec ific chaperones exist in yeast that route copper ions to the site of b iosynthesis of copper-metalloenzymes.