ACUTE HEPATITIS, AUTOIMMUNE HEMOLYTIC-ANEMIA, AND ERYTHROBLASTOCYTOPENIA INDUCED BY CEFTRIAXONE

Authors
LONGO F HASTIER P BUCKLEY MJM CHICHMANIAN RM DELMONT JP
Citation
F. Longo et al., ACUTE HEPATITIS, AUTOIMMUNE HEMOLYTIC-ANEMIA, AND ERYTHROBLASTOCYTOPENIA INDUCED BY CEFTRIAXONE, The American journal of gastroenterology, 93(5), 1998, pp. 836-837
Citations number
5
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
The American journal of gastroenterology → ACNP
ISSN journal
00029270
Volume
93
Issue
5
Year of publication
1998
Pages
836 - 837
Database
ISI
SICI code
0002-9270(1998)93:5<836:AHAHAE>2.0.ZU;2-C
Abstract
An 80-yr-old man developed acute hepatitis shortly after ingesting ora l ceftriaxone. Although the transaminases gradually returned to baseli ne after withholding the beta lactam antibiotic, there was a gradual i ncrease in serum bilirubin and a decrease in hemoglobin concentration caused by an autoimmune hemolytic anemia and erythroblastocytopenia. T hese responded to systemic steroids and immunoglobulins. Despite the w idespread use of these agents this triad of side effects has not previ ously been reported in connection with beta lactam antibiotics. (C) 19 98 by Am. Cell. of Gastroenterology.