THYROID-HORMONE STIMULATES PHOSPHOGLYCERATE MUTASE ACTIVITY AND ISOZYME TRANSITION IN RAT MUSCLE TISSUES

Authors
ESTELLER M URENA J CARRERAS J MARTELLY I CLIMENT F
Citation
M. Esteller et al., THYROID-HORMONE STIMULATES PHOSPHOGLYCERATE MUTASE ACTIVITY AND ISOZYME TRANSITION IN RAT MUSCLE TISSUES, Life sciences, 54(8), 1994, pp. 533-538
Citations number
28
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
8
Year of publication
1994
Pages
533 - 538
Database
ISI
SICI code
0024-3205(1994)54:8<533:TSPMAA>2.0.ZU;2-V
Abstract
Triiodothyronine (T3) increases phosphoglycerate mutase (PGAM) specifi c activity in rat skeletal and cardiac muscles. This increase is conco mitant with an increase in the proportion of phosphoglycerate mutase i sozymes which contain type-M subunit. Propylthiouracil (PTU), an anti- hormone, not only decreases phosphoglycerate mutase activity with resp ect to control rats, but also decreases the total M subunit contents. In liver, which only possesses type-B subunit phosphoglycerate mutase, none of the effects were detected.