SYNTHESIS OF A C-DISACCHARIDE GLYCOSYL DONOR AS A KEY BUILDING-BLOCK FOR THE PREPARATION OF NEW BIOLOGICALLY-ACTIVE HEPARIN PENTASACCHARIDEMIMETICS

The synthesis of the C-disaccharide imidate 34, a key synthon for the synthesis of heparin pentasaccharide mimetics, is described. The C-int erglycosidic bond was established through 9-endo-trig radical cyclizat ion from two tethered monosaccharides. It was followed by conversion o f the reducing end glucose unit into the required glucuronic acid deri vative.