PRIMARY MANIFESTATION OF HODGKINS-DISEASE IN THE CENTRAL-NERVOUS-SYSTEM

A 62-year-old woman presented with loss of memory and a mild hemipares is. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy s pecimens of this lesion revealed intracerebral Hodgkin's lymphoma, a d iagnosis supported by immunohistochemical reactions of the tumour cell s for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or E pstein-Barr virus infection was involved in the pathogenesis of this n eoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient h ad no evidence of Hodgkin's disease after 13 months of follow-up.