N. Tubridy et al., OPTIMIZATION OF UNENHANCED MRI FOR DETECTION OF LESIONS IN MULTIPLE-SCLEROSIS - A COMPARISON OF 5 PULSE SEQUENCES WITH VARIABLE SLICE THICKNESS, Neuroradiology, 40(5), 1998, pp. 293-297
Citations number
15
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Clinical Neurology
We used five MRI sequences in six patients with multiple sclerosis (MS
): conventional spin-echo (CSE) with 5-mm slices; 2D fast spin-echo (F
SE) with 2-mm slices; multishot T2-weighted echo-planar imaging (EPI)
with 5-mm slices; fast fluid-attenuated inversion recovery (fFLAIR) w
ith 2-mm slices; and 3D fast spin-echo with 1.5mm-thick slices. A tota
l of 225 lesions were detected on CSE, 274 on 2D FSE, 137 on EPI, 385
on fFLAIR and 320 on 3D FSE. The EPI sequence was clearly the least se
nsitive and susceptibility artefact was a problem, particularly in the
brain stem and temporal lobes. Fast FLAIR displayed a much higher num
ber of supratentorial lesions (380) than 3D FSE (297), 2D FSE (264) or
CSE (211). However, in the posterior cranial fossa 3D FSE was the mos
t sensitive sequence (23 lesions), followed by CSE (14) and 2D FSE (10
), while fFLAIR (5) was extremely insensitive.