CHEMOKINE EXPRESSION IN ENDOTHELIAL-CELLS AND MONOCYTES IS DIFFERENTIALLY REGULATED

Endothelial cells play a critical role in the recruitment of immune ce lls due to their position at the interface between circulating cells a nd the inflamed tissue. In this study, human umbilical vein endothelia l cells (HUVECs) and human monocytes were used to investigate the role of various cytokines in the regulation of C-C and C-X-C chemokine pro duction. We have demonstrated that IL-4 and IL-10 negatively affect ce rtain monocyte-derived chemokines, while not suppressing HUVEC-derived chemokines. The differential induction of chemokines by selected cyto kines may help delineate the type(s) of leukocytes that are recruited during certain phases of an inflammatory response.