PLATELET-DERIVED GROWTH-FACTOR AND ITS RECEPTOR - STRUCTURE AND ROLESIN NORMAL GROWTH AND PATHOLOGY

Authors
KHACHIGIAN LM CHESTERMAN CN
Citation
Lm. Khachigian et Cn. Chesterman, PLATELET-DERIVED GROWTH-FACTOR AND ITS RECEPTOR - STRUCTURE AND ROLESIN NORMAL GROWTH AND PATHOLOGY, Platelets, 4(6), 1993, pp. 304-315
Citations number
207
Categorie Soggetti
Hematology
Journal title
Platelets → ACNP
ISSN journal
09537104
Volume
4
Issue
6
Year of publication
1993
Pages
304 - 315
Database
ISI
SICI code
0953-7104(1993)4:6<304:PGAIR->2.0.ZU;2-K
Abstract
Platelet-derived growth factor (PDGF) is a pleotropic mitogen involved in several normal processes and pathological settings which include e mbryonal development, wound healing, atherosclerosis and neoplasia. We have reviewed the literature on the structure, function and regulatio n of PDGF and its receptors, and the roles played by PDGF in these set tings.