DEVELOPMENTAL-CHANGES IN REFRACTORINESS OF THE NEUROMAGNETIC M100 IN CHILDREN

CONSIDERABLE evidence exists for developmental changes in latency and amplitude of the auditory evoked potential termed N100. However, it is widely recognized that the N100 wave comprises multiple, temporally o verlapping neural generators, and few data are available addressing ei ther individual generator development or mechanisms behind such change . Using magnetoencelphalographic (MEG) measurements of the magnetic an alog of the N100 termed the M100, which derives primarily from supra-t emporal auditory generators, it is demonstrated here that changes in t he response of that waveform to manipulation of interstimulus interval (ISI) occur between the ages of 6 and 18 years of age. (C) 1998 Rapid Science Ltd.