Citation
M. Engman et al., DETERMINATION OF ROPIVACAINE AND [H-2(3)]ROPIVACAINE IN BIOLOGICAL SAMPLES BY GAS-CHROMATOGRAPHY WITH NITROGEN-PHOSPHORUS DETECTION OR MASS-SPECTROMETRY, Journal of chromatography B. Biomedical sciences and applications, 709(1), 1998, pp. 57-67
Citations number
29
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications
ISSN journal
13872273
→ ACNP
Volume
709
Issue
1
Year of publication
1998
Pages
57 - 67
Database
ISI
SICI code
0378-4347(1998)709:1<57:DORA[I>2.0.ZU;2-R
Abstract
Bioanalytical methods for determining the total concentration of the n
ew local anaesthetic drug ropivacaine in blood plasma, urine and tissu
es are presented. Ropivacaine is a drug mainly used in connection with
surgery and for post-operative pain relief. The biological samples we
re prepared using liquid-liquid extraction and analysed using capillar
y gas chromatography with nitrogen-phosphorus detection or mass spectr
ometry, The methods are highly selective and reliable with a between-d
ay precision, given as the relative standard deviation, generally belo
w 6%. More than 20000 samples have been analysed using the methods des
cribed. (C) 1998 Elsevier Science B.V.