A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes

Citation
A. Dmochowska et al., A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes, ACT BIOCH P, 46(1), 1999, pp. 155-162
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ACTA BIOCHIMICA POLONICA
ISSN journal
0001527X → ACNP
Volume
46
Issue
1
Year of publication
1999
Pages
155 - 162
Database
ISI
SICI code
0001-527X(1999)46:1<155:AHPSRH>2.0.ZU;2-9
Abstract
We have cloned and sequenced a cDNA of the human homologue of the Saccharom yces cerevisiae Suv3 putative RNA helicase which is indispensable for mitoc hondrial function in yeast. The human Suv-3-like protein has a typical mito chondrial leader sequence. Northern blot data and analysis of ESTs in the d ata banks indicate that this human gene (SUPV3L1) is expressed in practical ly all tissues, though at different levels. Sequence homology analysis has shown a strong conservation of the protein in a number of eukaryotic organi sms - plants, mammals and fungi, but no close homologues exist in bacteria with the exception of the purple bacterium Rhodobacter sphaeroides. This ge ne is thus ubiquitously present in all eukaryotic organisms.