Serum levels of soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukin-2 receptor in patients with vernal keratoconjunctivitis and allergic conjunctivitis
E. Uchio et al., Serum levels of soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukin-2 receptor in patients with vernal keratoconjunctivitis and allergic conjunctivitis, ALLERGY, 54(2), 1999, pp. 135-141
Background: Vernal keratoconjunctivitis (VKC) is characterized by severe oc
ular allergic inflammation that may have a poor visual prognosis. Due to th
e high frequency of the presence of atopic dermatitis (AD) in VKC, most sys
temic parameters are dependent on the clinical severity of AD.
Methods: Serum levels of sICAM-1, sVCAM-1, and sIL-2R were measured by enzy
me-linked immunoassay using samples from 30 VKC patients, 30 allergic conju
nctivitis (AC) patients, and 20 normal subjects, to determine whether the c
oncentrations of these molecules are elevated.
Results: Circulating slCAM-1 and sIL-2R levels were increased in patients w
ith VKC with AD compared with those in VKC without AD, AC, and normal contr
ols. Serum levels of sVCAM-1 in VKC patients with and without AD were signi
ficantly higher than those in controls. No significant difference was found
in the levels of sVCAM-1 between patients with VKC with and without AD. In
VKC patients with AD, the sIL-2R level correlated significantly with sever
ity of AD, whereas no such correlation was found for slCAM-1 and sVCAM-1.
Conclusions: These results suggest that serum sVCAM-1 can be used as a mark
er to differentiate VKC from nonproliferative ocular allergic diseases, and
specific immunologic features of VKC may underlie the upregulation of seru
m sVCAM-1.