Model for the regulation of energy balance and adiposity by the central nervous system

In 1995, we described a new model for adiposity regulation. Since then, dat a regarding the biology of body weight regulation has accumulated at a rema rkable rate and has bath modified and strengthened our understanding of ibi s homeostatic system. In this review we integrate new information into a re vised model for further understanding this important regulatory process. Ou r model of energy homeostasis proposes that long-term adiposity-related sig nals such as insulin and leptin influence the neuronal activity of central effector pathways that serve as controllers of energy balance.