Jl. Shapiro et al., CD5(-) B-Cell lymphoproliferative disorders presenting in blood and bone marrow - A clinicopathologic study of 40 patients, AM J CLIN P, 111(4), 1999, pp. 477-487
Citations number
32
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
We studied 40 patients with CD5(-) B-cell lymphoproliferative disorders (B-
LPDs) presenting in blood or bone marrow and 28 control patients with CD5() B-cell chronic lymphocytic leukemia (CLL). Fifteen study patients had mor
phologic features typical of CLL. The 15 patients with CD5(-) CLL were olde
r and had lower absolute lymphocyte counts and more advanced-stage disease
at diagnosis than controls. Ten study patients had morphologic features sug
gesting mantle cell lymphoma (MCL); 3 were Eater given a diagnosis of MCL b
ased on lymph node biopsy results. The 10 patients with CD5(-) MCL were old
er and at a more advanced stage than CLL control patients. The remaining 15
study patients were given the following diagnoses: circulating non-Hodgkin
lymphoma, 5; splenic lymphoma with villous lymphocytes, 5; lymphoplasmacyt
oid lymphoma, 3; and CLL/ pro-lymphocytic leukemia, 2. For the patients wit
h CD5(-) B-LPDs with morphologic features and manifestations resembling CLL
, we prefer the term CD5(-) CLL variant because of clinical and immunopheno
typic differences. Patients with CD5(-) B-LPDs with atypical nuclear morpho
logic features may represent the leukemic phase of MCL. Since CD23 is expre
ssed in most patients with CD5(-) B-LPD, its use in subclassifying these di
sorders seems limited.