Association study of the 5-HT6 receptor gene in schizophrenia

Serotonergic (5-hydroxytryptamine; 5-HT) transmission may play an important role in the treatment and/or pathogenesis of schizophrenia. Previous studi es reported that several atypical antipsychotic agents have high affinities for the 5-HT6 receptor. The 5-HT6 receptor gene polymorphism might contrib ute to the genetic background of this disorder. One hundred and fifty unrel ated patients with schizophrenia and 150 unrelated healthy controls were ge notyped for a biallelic polymorphism (267C/T) at the 5-HT6 receptor gene. N o significant positive association between the 5-HT6 receptor genotype and schizophrenia was observed. Our results suggests that the 267C/T polymorphi sm of the 5-HT6 receptor gene may not be involved in the susceptibility to schizophrenia. (C) 1999 Wiley-Liss, Inc.