Genetic correlation in otosclerosis

Purpose: The aim of this study was to determine the relationship of HLA typ ing in patients with otosclerosis. Materials and Methods: We used a prospective study in which HLA typing of 1 00 surgically confirmed otosclerosis patients were compared with age and se x matched normal individuals. Results: HLA-AB, HLA-AS, HLA-A11, and HLA-B13 were found to be significantl y higher (P <.05, .01, and .01, respectively). HLA-A9 and HLA-A11 were foun d to be higher (P <.01) in patients with a positive family history, indicat ing genetic heterogenicity. Conclusions: Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component. (Am J Otolaryngol 1999;20:102-105. Copyright (C) 199 9 by W.B. Saunders Company).