A randomized clinical trial of dermal anesthesia by iontophoresis for peripheral intravenous catheter placement in children

Study objective: To assess the efficacy of dermal anesthesia by lidocaine i ontophoresis in children undergoing peripheral intravenous (PIV) catheter p lacement in the emergency department. Methods: A double-blind, randomized, clinical trial was conducted at a tert iary children's hospital ED. Alert children 7 years or older requiring none mergency PIV were eligible. Patients in the lidocaine group received 1 mi o f 2% lidocaine with 1:100,000 epinephrine over a potential PIV site by iont ophoresis. The control group received 1 mi of .9% saline solution with 1:10 0,000 epinephrine. After PIV placement, patients ranked the procedural pain using a visual analog scale. Complications were noted by visual inspection or telephone follow-up. Results: During a 6-month period, 22 patients were assigned to the lidocain e group and 25 to the control group. There was no significant difference in age, sex, or ethnic background between the 2 study groups, and mean applic ation time was 12.0 minutes. The median pain score was .5 in the lidocaine group compared with 4 in the control group (P=.0002; 95% confidence interva l [CI]1 to 5). No significant immediate or delayed complications were obser ved. Conclusion: Lidocaine iontophoresis provides effective dermal anesthesia fo r children older than 7 years of undergoing nonemergency PIV placement in t he ED.