Growth in Sotos syndrome

Although there are several reports on infant and childhood growth in patien ts with Sotos syndrome, there is little information on the final height ach ieved and puberty. Growth data on 40 patients (20 female and 20 male) aged 2-31 years were collected. These showed that patients with Sotos syndrome a re excessively tall at birth, during infancy, and during childhood. Disprop ortionately long limbs constitute much of the increase in stature. However, the combination of advanced bone age and early onset of menarche led to a mean (SD) final height of 172.9 (5.7) cm in women. This is within the norma l range for the population. Most of the men also attained a final height (m ean, 184.3 cm; SD, 6.0) within the normal range, although exceptions were m ore likely in men than in women. Therefore, these results show that most pa tients with Sotos syndrome do not require intervention to limit their adult height.