Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: Synthesis and biological activities of triazine derivatives

Authors
Leroux, F van Keulen, BJ Daliers, J Pommery, N Henichart, JP
Citation
F. Leroux et al., Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: Synthesis and biological activities of triazine derivatives, BIO MED CH, 7(3), 1999, pp. 509-516
Citations number
38
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
3
Year of publication
1999
Pages
509 - 516
Database
ISI
SICI code
0968-0896(199903)7:3<509:P4IAAS>2.0.ZU;2-N
Abstract
A series of triazine derivatives was synthesized. The compounds were evalua ted for tracheal smooth muscle relaxant and type 4 phosphodiesterase inhibi tory activities. A highly significant correlation was observed between the two effects. Two compounds exhibited potent relaxant activity (EC50: 17 and 24 nM) and might be useful for the treatment of asthma. (C) 1999 Elsevier Science Ltd. All rights reserved.