Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid

Authors
Thomas, C Hubner, H Gmeiner, P
Citation
C. Thomas et al., Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid, BIOORG MED, 9(6), 1999, pp. 841-846
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
6
Year of publication
1999
Pages
841 - 846
Database
ISI
SICI code
0960-894X(19990322)9:6<841:EADDDD>2.0.ZU;2-T
Abstract
Subreceptor selectivity tuning of N-(3 -pyrrolidinyl)benzamides leading to the selective dopamine D3 ligand entlh and the derivatives 1g and 1e/entle which preferably recognize human D2 or D4 receptors, respectively, is descr ibed. Binding profiles were controlled by both, absolute and relative confi guration. The enantiopure target compounds were synthesized from aspartic a cid. (C) 1999 Elsevier Science Ltd. All rights reserved.