Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action.

Authors
Player, MR Torrence, PF
Citation
Mr. Player et Pf. Torrence, Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action., BIOORG MED, 9(6), 1999, pp. 891-894
Citations number
35
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
6
Year of publication
1999
Pages
891 - 894
Database
ISI
SICI code
0960-894X(19990322)9:6<891:POIRLT>2.0.ZU;2-6
Abstract
Phosphorothioate oligodeoxyribonucleotides were found to be inhibitors of t he 2-5A-dependent RNase L. Inhibitory potency depended upon the chain lengt h of the phosphorothioate oligonucleotide and was dependent on the phosphor othioate substitution pattern, but was not substantially base-dependent. (C ) 1999 Elsevier Science Ltd. All rights reserved.