The aim of this study was to determine the incidence of polydipsia in 49 au
tistic children, and also the influence of psychotropic drugs and residenti
al factors on water drinking behavior, as compared with in 89 mentally reta
rded children, in schools for mentally handicapped children in Fukui prefec
ture. Questionnaires were used to detect polydipsia and to assess the sever
ity of the water drinking behavior in the autistic children and mentally re
tarded children. The incidence of polydipsia in the autistic children tende
d to be higher (P = 0.074) than that in the retarded children. The severity
of water drinking behavior was significantly higher in autism (P = 0.022)
than in mental retardation. The majority of the autistic children with poly
dipsia had been taking no psychotropic drugs. The incidence of polydipsia s
howed no significant difference between two residential situations, i.e. 'n
ot at home' and 'at home'. The present study suggests that polydipsia or ex
cessive water drinking behavior occurs more often in autism than in mental
retardation, possibly due to some intrinsic factor in autism itself. (C) 19
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