Nasal-type Tnatural killer cell angiocentric lymphoma, Epstein-Barr virus-associated, and showing clonal T-cell receptor gamma gene rearrangement

Nasal-type T/natural killer (NK) cell lymphoma, which often shows an angioc entric growth pattern, is a distinct clinicopathological entity highly asso ciated with the Epstein-Barr virus (EBV). This tumour has a characteristic immunophenotype, whereas the cytological spectrum is broad. It is known tha t a clonal T-cell receptor (TCR) gene rearrangement is not found in this tu mour. However, it is still unresolved as to whether the finding of a clonal TCR gene rearrangement excludes the diagnosis of nasal-type T/NK cell lymp homa. We describe a case of nasal-type T/NK cell angiocentric lymphoma, EBV -associated, and showing clonal TCR gamma gene rearrangement. The patient d ied of sepsis 5 months after diagnosis in spite of aggressive chemotherapy.