E. Ozkaya-bayazit et al., Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine, BR J DERM, 140(3), 1999, pp. 525-530
Annular elastolytic giant cell granuloma is a rare granulomatous skin disea
se characterized by phagocytosis of elastic fibres by multinucleated giant
cells. Lesions are either solitary or grouped in a few annular patches with
elevated borders and central atrophy. Sun-exposed areas are more commonly
involved than covered skin. The pathogenesis of the disease is still contro
versial. We report a 72-year-old fair-skinned woman with unusual clinical f
indings. An irregularly shaped erythematous plaque covered the entire face,
and hundreds of lichenoid papules were present on both sun-exposed and cov
ered areas which gradually evolved into annular lesions of about 0.5-1 cm i
n diameter. Sparing of an old burn scar and a nearly complete lack of elast
ic fibres in the scar site were noted, illustrating the presumed importance
of dermal elastic tissue in the pathogenesis. The course of the disease is
chronic. Several treatments have been tried, with variable success. In our
patient, improvement was achieved with chloroquine over a period of 16 wee
ks.