A prospective placebo controlled double blind randomised study to investigate the use of indoramin to prevent post-operative voiding disorders after surgical treatment for genuine stress incontinence

A prospective placebo controlled double blind randomised study was undertak en to investigate the use of indoramin an alpha blocker to prevent post-ope rative voidine disorders after surgical treatment for genuine stress incont inence. Fifty-six patients were randomised to receive indoramin 20 mg orall y twice a day or identical placebo from the first post-operative day until discharge from hospital. After seven exclusions, 49 patients were included in the study. There was no significant difference between the treatment (in doramin) group and placebo group for any of the outcomes measured. The rout ine use of indoramin to prevent post-operative voiding problems cannot be j ustified on the basis of these data.