Plasmodium falciparum resistance to chloroquine and cycloguanil in patients returning to France after a travel in Africa without chemoprophylaxis.

Authors
Le Bras, J Pradines, B di Piazza, JP Durand, R Godineau, N Bouchaud, O Roue, R Marchou, B Martet, G Longuet, C Parzy, D
Citation
J. Le Bras et al., Plasmodium falciparum resistance to chloroquine and cycloguanil in patients returning to France after a travel in Africa without chemoprophylaxis., B S PATH EX, 91(5BIS), 1998, pp. 490-492
Citations number
15
Categorie Soggetti
Envirnomentale Medicine & Public Health
Journal title
BULLETIN DE LA SOCIETE DE PATHOLOGIE EXOTIQUE
ISSN journal
00379085 → ACNP
Volume
91
Issue
5BIS
Year of publication
1998
Pages
490 - 492
Database
ISI
SICI code
0037-9085(199812)91:5BIS<490:PFRTCA>2.0.ZU;2-W
Abstract
The in vitro susceptibility of chloroquine and the genomic profile of dihyd rofolate reductase (DHFR) codon 108 was determined against african isolates of P. falciparum (Pf) from imported malaria cases without previous drug in take by an isotopic microtest or PCR + RFLP. Pf resistance to chloroquine o r to the DHFR inhibitor was present in 49% and 46% of isolates, respectivel y. Pf drug resistance was more frequent in permanent than in seasonal malar ial transmission areas and chloroquine plus DHFR resistance reached 28% in years 1995-97. Updating the guidelines for the prevention of malaria in tra vellers to Africa is necessary.