Dermatofibrosarcoma protuberans harboring t(9;22)(q32;q12.2)

More than 20 cases of dermatofibrosarcoma protuberans (DFSP) exhibiting chr omosomal abnormalities have been reported. Approximately three fourths of t hese tumors have harbored supernumerary ring chromosomes, which have been s uggested to be specific for this tumor. However, a small number of DFSPs wi th translocations such as t(2;17), t(X;7), and t(17;22) have recently been reported. We report a DFSP arising in a 23-year-old woman which unexpectedl y exhibited the balanced translocation, t(9;22)(q32;q12.2) as the only anom aly with G-band technique. Dual-color fluorescence in situ hybridization: ( FISH) confirmed these cytogenetic findings. Similar to that previously repo rted for DFSPs with translocations, the present tumor also lacked ring chro mosomes. (C) Elsevier Science Inc., 1999. All rights reserved.