Cytogenetic findings in five patients with hairy cell leukemia

Authors
Sole, F Woessner, S Florensa, L Espinet, B Lloveras, E Pedro, C Besses, C Sabrafen, JS
Citation
F. Sole et al., Cytogenetic findings in five patients with hairy cell leukemia, CANC GENET, 110(1), 1999, pp. 41-43
Citations number
26
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
110
Issue
1
Year of publication
1999
Pages
41 - 43
Database
ISI
SICI code
0165-4608(19990401)110:1<41:CFIFPW>2.0.ZU;2-4
Abstract
We studied five cases of hairy cell leukemia (HCL) using conventional cytog enetics. All patients were diagnosed with typical HCL. Chromosome analysis was carried out on a 72-hour culture of peripheral blood. Phytohemagglutini n (PHA) mitogen was used. Clonal chromosome abnormalities were found in 2/5 patients (40%), a complex abnormality being identified in one of them. The chromosomes involved were: 1, 6, 7, 8, and 17. No patient showed trisomy 1 2 or a 14q+. An interesting result was the finding of del(7)(q32) as a sole anomaly. (C) Elsevier Science Inc., 1999. All rights reserved.