Polyploidization and losses of chromosomes 1, 2, 6, 10, 13, and 17 in three cases of chromophobe renal cell carcinomas

Clonal chromosome aberrations identified after short-term culture are prese nted for three cases of chromophobe renal cell carcinomas (RCC). All tumors revealed abnormal karyotypes with a varying proportion of polyploid tumor cells. Common numerical abnormalities were combined losses of chromosomes 1 , 2, 6, 10, 13, and 17. Clonal karyotypic evolution was demonstrated in one case in which several related clones could be identified. An additional ba lanced translocation t(3;14)(p24;q22) observed in this case proved to be of constitutional nature by cytogenetic analysis of normal kidney cells and p eripheral blood lymphocytes. These cytogenetic findings provide further evi dence that chromophobe renal cell carcinomas are characterized by a highly specific combination of chromosomal losses most commonly including chromoso mes 1, 2, 6, 10, 13, and 17. (C) Elsevier Science Inc., 1998.