Treatment results and prognostic factors in inoperable carcinoma of the cervix treated with external plus high dose brachytherapy

Patients with inoperable carcinoma of the cervix treated with external plus high dose rate brachytherapy (HDRB), between 1988 and 1995 were evaluated retrospectively. According to stage, 5 year survival rates were 67.3% in st age IIb and 52.6% in stage III (P = 0001) and disease free survival (DFS) r ates were 54.0% in stage IIb and 43.9% in stage III (P = 0.01), The followi ng parameters were studied: age; stage; external beam dose; brachytherapy d ose; total dose to point A; tumor mass; tumor response rate; bilateral or u nilateral invasion of parametria in stage IIb; and bilateral or unilateral invasion of pelvic wall in stage mb; and the existence of hydronephrosis. T he only significant parameter of 5 year survival and local control was tumo r mass (P = 0.003). (C) 1999 Published by Elsevier Science Ireland Ltd, All rights reserved.