Deficient platelet-activating factor and related enzymes in hemimegalencephaly

Authors
Hirashima, Y Endo, S Karasawa, K Sato, N Yokoyama, K Kurimoto, M Ikeda, H Setaka, M Takaku, A
Citation
Y. Hirashima et al., Deficient platelet-activating factor and related enzymes in hemimegalencephaly, CHILD NERV, 15(2-3), 1999, pp. 98-101
Citations number
16
Categorie Soggetti
Pediatrics
Journal title
CHILDS NERVOUS SYSTEM
ISSN journal
02567040 → ACNP
Volume
15
Issue
2-3
Year of publication
1999
Pages
98 - 101
Database
ISI
SICI code
0256-7040(199903)15:2-3<98:DPFARE>2.0.ZU;2-7
Abstract
Platelet-activating factor (PAF) may influence neuronal migration, and gyra l anomaly in hemimegalencephaly is believed to result from a neuronal disor der. A 7-month-old girl with hemimegalencephaly presented with intractable seizures, for which graded hemispherectomy was performed. In the resected s pecimen, we could not detect PAF, and related enzyme activities were low. T hese results suggest a role of PAF in neuronal migration.