Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein
T. Hada et al., Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein, CLIN CHIM A, 281(1-2), 1999, pp. 37-46
We have previously reported that Aleuria aurantia lectin (AAL)-reactive ser
um cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepa
tocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal
controls (NC), and measurement of AAL-reactive ChE activity is useful in di
scriminating LC from CH. In the present study, Ive have demonstrated that t
he measurement of the ratio of AAL-reactive ChE to immuno-reactive ChE prot
ein (AAL/ChE) is superior to the measurement of only AAL-reactive ChE for d
ifferentiating LC from CH. At a cut-off value of 4.0 arbitrary units of AAL
/ChE, the diagnostic accuracy was 87.7%. This diagnostic accuracy is simila
r to that of serum hyaluronan, 88.8%. We also examined whether the AAL/ChE
measurement is useful for differentiating Child's stage A LC from chronic a
ctive hepatitis (CAH) 2B. When mean + 2SD of AAL/ChE in patients with CAH2B
was used as a cut-off value for the specific diagnosis of LC, the diagnost
ic accuracy was 70.2%. These results demonstrate that measurement of AAL/Ch
E is useful for discriminating LC from CH. (C) 1999 Elsevier Science B.V. A
ll rights reserved.