A framework for generating and optimizing chemical plant process connectivi
ty is presented. The method addresses plant synthesis and analysis for mult
istep processes, processes where multiple reactions occur in both series an
d parallel, and where interstitial separation operations may be required. T
he method is tailored for the initial stages of process design, whereupon l
imited development of the process flowsheet has occurred, and estimation of
plant economic viability is required. The chemical process is modeled as a
n interconnected graph linking chemical component nodes to operating sectio
ns. A mixed integer non linear program is utilized to obtain 'best' flowshe
et configurations with initial mass balances and estimations for reactor pa
rameters. The method is illustrated by examining large scale continuous pro
cesses, with the hydrodealkylation of toluene (HDA) process and a multistag
e chloromethanes process presented as case studies. (C) 1999 Elsevier Scien
ce Ltd. All rights reserved.