Structural and energetic determinants of the S-1-site specificity in serine proteases

Citation
H. Czapinska et J. Otlewski, Structural and energetic determinants of the S-1-site specificity in serine proteases, EUR J BIOCH, 260(3), 1999, pp. 571-595
Citations number
162
Categorie Soggetti
Biochemistry & Biophysics
Journal title
EUROPEAN JOURNAL OF BIOCHEMISTRY
ISSN journal
00142956 → ACNP
Volume
260
Issue
3
Year of publication
1999
Pages
571 - 595
Database
ISI
SICI code
0014-2956(199903)260:3<571:SAEDOT>2.0.ZU;2-I
Abstract
In recent years the number of determined three-dimensional structures of se rine proteases that are accompanied by detailed mutational studies has grow n rapidly. In particular, spatial structures have been described for enzyme s involved in processes of critical medical significance, often related to severe pathophysiological diseases. There has also been significant progres s in the understanding of the structural grounds for the substrate specific ity of serine proteases. This review is concerned mainly with primary struc tural determinants of the S-1 specificity, the crucial component of substra te selectivity, often in relation to more distant specificity elements, whi ch cooperatively influence the S-1 site.