EFFECT OF TENOXICAM AND INDOMETHACIN ON THE CHEMOTAXIS INDUCED BY SUBSTANCE-P AND INTERLEUKIN-8 ON HUMAN MONOCYTES AND POLYMORPHONUCLEAR CELLS

The neuropeptide substance P and the cytokine interleukin-8 are potent chemotactic factors for monocytes and/or polymorphonuclear cells. The y are present in the synovial fluid of arthritic patients, and partici pate in the pathogenesis of arthritis. We investigated in vitro the ef fect of two non-steroidal antiinflammatory drugs, tenoxicam and indome thacin, on the chemotactic effect of substance P and interleukin-8 at concentrations that can be reached in the synovial fluid of arthritic patients. Both drugs decreased the chemotaxis induced by substance P a nd interleukin-8 at concentrations that can be reached in the synovial fluid during therapy. This result could be of importance for the use of these two non-steroidal antiinflammatory drugs in studying the deve lopment and progress of arthritic disease.