Comparative multicenter trial of teicoplanin versus cefazolin for antimicrobial prophylaxis in prosthetic joint implant surgery

A randomized multicenter study was carried out in 12 centers in Italy to co mpare administration of a single dose of teicoplanin (400 mg i.v. bolus at time of anesthesia) versus that of five doses of cefazolin over a 24-h peri od (2 g at induction of anesthesia and Ig every 6 h postoperatively, i.v. b olus) as antimicrobial prophylaxis in patients undergoing hip or knee arthr oplasty. Of 860 patients enrolled, 427 received teicoplanin and 433 cefazol in. A total of 846 patients (422 teicoplanin and 424 cefazolin) were evalua ble for safety and 826 patients for efficacy. Six patients (1.5%) in the te icoplanin group and seven patients (1.7%) in the cefazolin group developed a surgical wound infection during their postoperative hospital stay: this d ifference was not significant. Proven or suspected infections involving oth er body systems occurred in 114 patients (57 in each group). Seven hundred ninety-two patients completed a 3-month evaluation and 738 patients a 12-mo nth evaluation; the success rates in evaluable patients at these observatio n times were 99.2% and 99.7% for teicoplanin and 99.2% and 99.7% for cefazo lin, respectively. Adverse events occurred in three (0.7%) teicoplanin pati ents and nine (2.1%) cefazolin patients (P=0.083). A single preoperative do se of teicoplanin ensures adequate surgical antisepsis, with results compar able to a standard multiple-dose regimen of cefazolin.