Pharmacokinetics of oxypolygelatine in healthy volunteers

Objective/methods: The pharmacokinetics of the plasma substitute oxypolygel atine (OPG) were studied in 12 healthy volunteers after single-dose adminis tration of 27 ml.kg(-1) body weight, with a maximum of 2000 mi. OPG was det ermined in plasma and urine over 48 h after the infusion. Peak plasma OPG c oncentrations at the end of the infusion were determined to 4.600 (623) mu g.ml(-1), the area under the plasma concentration/time curve (AUC(0-infinit y)) was calculated to 70.135 (15.861) mu g.h.ml(-1). Results: The model-independently calculated volume of distribution came to 23.1 (4.8) 1 with a clearance total is (Cl-tot) of 24.6 (6.8) ml.min(-1). T he initial half-life according to a three-compartment model came to 0.3 (0. 2) h, followed by a distribution half-life of 3.1 (2.6) h and a terminal el imination half-life of 13.4 (2.2) h. Cumulative urinary excretion of OPG wa s 64% after 48 h. Conclusion. This low recovery rate may be explained by the distribution of OPG into the extravascular space and subsequent degradation in tissue sites .