Genetic polymorphism of human complement factor I (C3b inactivator) in theChinese Han population

The human complement factor I (IF) polymorphism has been analysed by polyac rylamide get isoelectric focusing electrophoresis of neuraminidase-treated EDTA plasma samples followed by immunoblotting and enzymatic detection. In a population study among 121 random individuals from Chengdu, PR China, th ree different common phenotypes were observed. The results show that IF is polymorphic in the Chinese population. The allele frequencies were as follo ws: FI*A = 0.153, FI*B = 0.847, The distribution of observed phenotypes was in accordance with the Hardy-Weinberg equilibrium. In comparison to other Asian population studies, the frequency of the IF*A allele was the highest in the Chinese population studied here.