Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue

Several different disease loci with unknown genetic background map to human Xp11. In a systematic search for novel genes, we identified a novel transc ript, UXT (HGMW-approved symbol), close to the ELK1 locus in Xp11.23-p11.22 . The gene is composed of seven exons and encodes a protein of 157 amino ac ids, which is highly conserved in mouse. We showed that UXT is ubiquitously expressed and subject to X-inactivation, No homology to any known genes wa s found. Database surveys indicate an abundant expression in tumor tissues. (C) 1999 Academic Press.