Mj. Silverstein et al., 10-YEAR RESULTS COMPARING MASTECTOMY TO EXCISION AND RADIATION-THERAPY FOR DUCTAL CARCINOMA IN-SITU OF THE BREAST, European journal of cancer, 31A(9), 1995, pp. 1425-1427
The 10-year results of 300 patients with ductal carcinoma in situ (DCI
S) without microinvasion are reported; 167 treated with mastectomy and
133 treated with excision and radiation therapy. There was a signific
ant difference in disease-free survival at 10 years, in favour of thos
e treated with mastectomy, 98% versus 81% (P = 0.0004). Multivariate a
nalysis confirmed nuclear grade as the only significant predictor of l
ocal recurrence (P = 0.02) or invasive local recurrence (P = 0.03) in
patients with DCIS treated with excision and radiation therapy. There
was no difference in breast cancer-specific survival or overall surviv
al between the two treatment groups.