10-YEAR RESULTS COMPARING MASTECTOMY TO EXCISION AND RADIATION-THERAPY FOR DUCTAL CARCINOMA IN-SITU OF THE BREAST

The 10-year results of 300 patients with ductal carcinoma in situ (DCI S) without microinvasion are reported; 167 treated with mastectomy and 133 treated with excision and radiation therapy. There was a signific ant difference in disease-free survival at 10 years, in favour of thos e treated with mastectomy, 98% versus 81% (P = 0.0004). Multivariate a nalysis confirmed nuclear grade as the only significant predictor of l ocal recurrence (P = 0.02) or invasive local recurrence (P = 0.03) in patients with DCIS treated with excision and radiation therapy. There was no difference in breast cancer-specific survival or overall surviv al between the two treatment groups.