PREVALENCE OF ANAPHYLAXIS ASSOCIATED WITH THE INTRAMUSCULAR ADMINISTRATION OF L-ASPARAGINASE TO 81 DOGS WITH CANCER - 1989-1991

Eighty-one dogs with histologically confirmed, measurable, malignant t umors were used in a prospective study to determine the prevalence of anaphylaxis associated with the intramuscular (IM) administration of 2 32 dosages of L-asparaginase (10,000 U/m2), an antineoplastic agent de rived from Escherichia coli. None of the dogs exhibited any clinical s igns associated with anaphylaxis. A partial or complete remission (gre ater than 50% reduction volume reduction) was obtained in 31 of 39 dog s (79%) with lymphoma that were given L-asparaginase prior to other ch emotherapeutic agents.