Antigen-based immunotherapy for autoimmune disease: from animal models to humans?

Insights into tolerance and autoimmune processes have led to novel immunoth erapeutics for inhibiting autoimmune disease in animal models. However, rec ent studies question the immune basis of some of these therapeutic strategi es and raise concerns about their efficacy and safety. Here, we discuss the feasibility of extending the success of antigen-based immunotherapeutics f or T-cell mediated autoimmune diseases from animal models to humans.