Immune cell signaling defects in lupus: activation, anergy and death

Authors
Tsokos, GC Liossis, SNC
Citation
Gc. Tsokos et Snc. Liossis, Immune cell signaling defects in lupus: activation, anergy and death, IMMUNOL TOD, 20(3), 1999, pp. 119-124
Citations number
42
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
3
Year of publication
1999
Pages
119 - 124
Database
ISI
SICI code
0167-5699(199903)20:3<119:ICSDIL>2.0.ZU;2-E
Abstract
Recent studies have identified novel aberrations in antigen receptor-mediat ed signaling events in lymphocytes from patients with systemic lupus erythe matosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ resp onses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in hu man lupus.