FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function

Authors
Zipfel, PF Skerka, C
Citation
Pf. Zipfel et C. Skerka, FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function, IMMUNOL TOD, 20(3), 1999, pp. 135-140
Citations number
45
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
3
Year of publication
1999
Pages
135 - 140
Database
ISI
SICI code
0167-5699(199903)20:3<135:FAHCAI>2.0.ZU;2-F
Abstract
A novel regulator of the alternative complement pathway with functions simi lar to that of factor H has been identified in human plasma. The cDNA encod ing this factor H-like protein 1(FHL-1/reconectin) was isolated several yea rs ago. Here, Peter Zipfel and Christine Skerka describe functional analyse s revealing that this novel complement regulatory protein forms a molecular link between immune defense and cell adhesion.