Direct and indirect recognition: the role of MHC antigens in graft rejection

Authors
Gould, DS Auchincloss, H
Citation
Ds. Gould et H. Auchincloss, Direct and indirect recognition: the role of MHC antigens in graft rejection, IMMUNOL TOD, 20(2), 1999, pp. 77-82
Citations number
28
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
2
Year of publication
1999
Pages
77 - 82
Database
ISI
SICI code
0167-5699(199902)20:2<77:DAIRTR>2.0.ZU;2-A
Abstract
In graft rejection, T-cell stimulation by donor APCs and self-APCs (present ing peptides of donor origin) has been called 'direct' and 'indirect' recog nition, respectively. Here, Dina Gould and Hugh Auchincloss consider the tr aditional arguments favoring direct recognition and highlight recent findin gs suggesting the importance of indirect responses, thereby questioning som e of our basic concepts of transplantation immunology.