Transcriptional enhancers and the evolution of the IgH locus

Authors
Magor, BG Ross, DA Pilstrom, L Warr, GW
Citation
Bg. Magor et al., Transcriptional enhancers and the evolution of the IgH locus, IMMUNOL TOD, 20(1), 1999, pp. 13-17
Citations number
35
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
1
Year of publication
1999
Pages
13 - 17
Database
ISI
SICI code
0167-5699(199901)20:1<13:TEATEO>2.0.ZU;2-Y
Abstract
Based on comparisons of the structure and transcriptional regulation of the IgH locus in mammals and a bony fish, Brad Magor and colleagues present a hypothesis in which enhancer evolution was the driving force in (and a prer equisite for) the development of the complex and flexible IgH locus seen in mammals.