Steroids treatment of granulomatous hepatitis complicating Coxiella burnetii acute infection

Granulomatous hepatitis associated with Coxiella burnetii acute infection h as an adverse clinical course in some patients. Surprisingly, it does not r espond to antibiotic but to steroids treatment. A hypersensitivity mechanis m has been implicated. A case of granulomatous hepatitis complicating C. bu rnetti acute infection is reported, which was refractory to antibiotics but , as in four other cases previously reported, showed a complete response to steroids. This case was found to support findings that moderate doses of s teroids can be useful in patients with granulomatous hepatitis complicating C. burnetii infection and showing no response to antibiotic treatment.