Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons

The extent of neuronal regeneration after axotomy largely depends on the su rvival capacity of the injured cell. It has been shown for a long time that nerve fiber transection results in retrograde changes in the parent neuron al cell body, and that these changes may eventually lead to neuronal degene ration.(13) At present, little is known about the sequence of events initia ted in a nerve cell body by the transection of its axonal process. In this report, we will focus on an interaction of nerve growth factor (NGF) with t he transcription factor c-Jun in intact and axotomized septohippocampal pro jection neurons. (C) 1999 ISDN. Published by Elsevier Science Ltd. All righ ts reserved.