TOTAL SYNTHESIS OF (-POLYOXIN-J STARTING FROM MYOINOSITOL())

Authors
CHIDA N KOIZUMI K KITADA Y YOKOYAMA C OGAWA S
Citation
N. Chida et al., TOTAL SYNTHESIS OF (-POLYOXIN-J STARTING FROM MYOINOSITOL()), Journal of the Chemical Society, Chemical Communications, (1), 1994, pp. 111-113
Citations number
36
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
1
Year of publication
1994
Pages
111 - 113
Database
ISI
SICI code
0022-4936(1994):1<111:TSO(SF>2.0.ZU;2-I
Abstract
The total synthesis of the antifungal antibiotic, polyoxin J 1 startin g from myo-inositol is described; the two key components, 2 and 3, wer e prepared from a pair of optically resolved myo-inositol derivatives 4L and 4D, respectively, using a highly regioselective Baeyer-Villiger reaction, and finally coupled to complete the total synthesis.