Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii

Authors
Qian-Cutrone, J Ueki, T Huang, S Mookhtiar, KA Ezekiel, R Kalinowski, SS Brown, KS Golik, J Lowe, S Pirnik, DM Hugill, R Veitch, JA Klohr, SE Whitney, JL Manly, SP
Citation
J. Qian-cutrone et al., Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii, J ANTIBIOT, 52(3), 1999, pp. 245-255
Citations number
7
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
3
Year of publication
1999
Pages
245 - 255
Database
ISI
SICI code
0021-8820(199903)52:3<245:GAABTN>2.0.ZU;2-J
Abstract
During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acy l CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were i solated from the butanol extracts of Streptomyces purpurogeniscleroticus WC 71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degrad ation. Glucolipsin A (1) and B (2) relieved the inhibition of glucokinase b y FAC with RC50 values of 5.4 and 4.6 mu M.